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Molecular docking, synthesis and biological evaluation of Vascular Endothelial Growth Factor (VEGF) B based peptide as antiangiogenic agent targeting the second domain of the Vascular Endothelial Growth Factor Receptor 1 (VEGFR1D2) for anticancer application

journal contribution
submitted on 2024-05-14, 05:26 and posted on 2024-05-14, 05:27 authored by Afsaneh Sadremomtaz, Ameena M. Ali, Foroozan Jouyandeh, Saeed Balalaie, Razieh Navari, Sylvain Broussy, Kamran Mansouri, Matthew R. Groves, S. Mohsen Asghari

Tumor angiogenesis is regulated by the binding of VEGF to receptors (VEGFRs). The major mediator of tumor angiogenesis is VEGFA, more commonly referred to as VEGF. VEGFR1 binds VEGF with higher affinity (10 times) than VEGFR2.1 However, the role of the VEGFR1 in VEGF-mediated angiogenesis remains a mystery.

Other Information

Published in: Signal Transduction and Targeted Therapy
License: https://creativecommons.org/licenses/by/4.0
See article on publisher's website: https://dx.doi.org/10.1038/s41392-020-0177-z

History

Language

  • English

Publisher

Springer Nature

Publication Year

  • 2020

License statement

This Item is licensed under the Creative Commons Attribution 4.0 International License.

Institution affiliated with

  • Hamad Bin Khalifa University
  • Qatar Biomedical Research Institute - HBKU