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Akkermansia, a Possible Microbial Marker for Poor Glycemic Control in Qataris Children Consuming Arabic Diet—A Pilot Study on Pediatric T1DM in Qatar

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Version 2 2023-09-27, 08:24
Version 1 2023-07-04, 11:52
journal contribution
revised on 2023-09-27, 08:23 and posted on 2023-09-27, 08:24 authored by Arun Prasath Lakshmanan, Amira Kohil, Farah El Assadi, Sara Al Zaidan, Shaikha Al Abduljabbar, Dhinoth Kumar Bangarusamy, Fawziya Al Khalaf, Goran Petrovski, Annalisa Terranegra

In Qatar, Type 1 Diabetes mellitus (T1DM) is one of the most prevalent disorders. This study aimed to explore the gut microbiome’s relation to the continuous subcutaneous insulin infusion (CSII) therapy, dietary habits, and the HbA1c level in the pediatric T1DM subjects in Qatar. We recruited 28 T1DM subjects with an average age of 10.5 ± 3.53 years. The stool sample was used to measure microbial composition by 16s rDNA sequencing method. The results have revealed that the subjects who had undergone CSII therapy had increased microbial diversity and genus Akkermansia was significantly enriched in the subjects without CSII therapy. Moreover, genus Akkermansia was higher in the subjects with poor glycemic control (HbA1c > 7.5%). When we classified the subjects based on dietary patterns and nationality, Akkermansia was significantly enriched in Qataris subjects without the CSII therapy consuming Arabic diet than expatriates living in Qatar and eating a Western/mixed diet. Thus, this pilot study showed that abundance of Akkermansia is dependent on the Arabic diet only in poorly controlled Qataris T1DM patients, opening new routes to personalized treatment for T1DM in Qataris pediatric subjects. Further comprehensive studies on the relation between the Arabic diet, ethnicity, and Akkermansia are warranted to confirm this preliminary finding.

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Published in: Nutrients
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Open Access funding provided by the Qatar National Library



  • English



Publication Year

  • 2021

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This Item is licensed under the Creative Commons Attribution 4.0 International License

Institution affiliated with

  • Sidra Medicine
  • Qatar University
  • Qatar University Health - QU
  • College of Health Sciences - QU HEALTH
  • Hamad Bin Khalifa University
  • College of Health and Life Sciences - HBKU

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