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Tracheoesophageal fistula and esophageal perforation in a patient with advanced gastroesophageal junction tumor post ramucirumab treatment. A case report and literature review

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submitted on 2023-11-02, 11:19 and posted on 2023-11-05, 05:18 authored by Ahmed Abdalhadi, Mouhammad J Alawad, Nabil E. Omar, Muhammed Hajmusa, Mohammed Gaber, Alaaeldin Shablak


Ramucirumab is an anti-angiogenic drug that received Food and Drug Administration (FDA)-approvals for treatments of many cancers. Gastrointestinal fistulas and perforations are recognized side effects of anti-angiogenic therapies, however, there are very few reported cases of these conditions in patients managed with Ramucirumab. Here we report a case of a 46-year-old gentleman with a stage four gastroesophageal junction tumor, who developed multiple tracheoesophageal fistulas post ramucirumab containing regimen. To the best of our knowledge, this is the first case report that describes a serious uncommon complication of ramucirumab in a patient with a gastroesophageal junction tumor.

Other Information

Published in: Current Problems in Cancer: Case Reports
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  • English



Publication Year

  • 2023

License statement

This Item is licensed under the Creative Commons Attribution 4.0 International License

Institution affiliated with

  • Hamad Medical Corporation
  • National Center for Cancer Care and Research - HMC
  • Medical Education - HMC
  • Qatar University
  • Qatar University Health - QU
  • College of Pharmacy - QU HEALTH