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Therapeutic Use of Extraembryonic-Derived Tissues

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submitted on 2024-05-29, 05:49 and posted on 2024-05-29, 05:50 authored by Michael Uhlin, Mohamed Abumaree, Essam M. Abdelalim

Instead as being seen as medical waste, umbilical cord blood (UCB), placenta-derived cells, and other extraembryonic tissue are increasingly accepted as a high-quality source of cells for therapeutic use. The best-known application is the transplantation of hematopoietic stem cells (HSCT), while UCB has become an increasingly important graft source since UCB transplantation (UCBT) has been implemented in the last 3 decades. Recently, UCB, placenta, and extraembryonic-derived cells and tissues have been also investigated as a source for adoptive cell therapy.

The nonhematopoietic stem cell types in UCB as well as placenta-derived and extraembryonic cells and tissues include several types that can be used therapeutically and are readily expanded to sufficient numbers using established methods. Most notable of these are mesenchymal stromal cells (MSCs) and endothelial-like vascular progenitors (EPCs). To complicate it further, MSCs from different sources of the placenta seem to have very different properties.

To even further potentiate the use of extraembryonic-derived tissues for therapy, the sources have to be elaborately characterized. In this special edition, the potential use for this kind of tissues in this was highlighted in several cases illustrating its role in future regenerative medicine. Examples of papers are published in this special edition.

Other Information

Published in: Stem Cells International
License: http://creativecommons.org/licenses/by/4.0/
See article on publisher's website: https://dx.doi.org/10.1155/2018/6082698

Funding

Open Access funding provided by the Qatar National Library.

History

Language

  • English

Publisher

Hindawi

Publication Year

  • 2018

License statement

This Item is licensed under the Creative Commons Attribution 4.0 International License.

Institution affiliated with

  • Hamad Bin Khalifa University
  • Qatar Biomedical Research Institute - HBKU
  • Diabetes Research Center - QBRI

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