Manara - Qatar Research Repository
1-s2.0-S0008874921001271-main.pdf (1.82 MB)

The role of PAK4 in the immune system and its potential implication in cancer immunotherapy

Download (1.82 MB)
journal contribution
submitted on 2023-10-29, 04:54 and posted on 2023-10-29, 10:00 authored by Azza Naїja, Maysaloun Merhi, Varghese Inchakalody, Queenie Fernandes, Sarra Mestiri, Kirti S. Prabhu, Shahab Uddin, Said Dermime

The p21 activated kinases (PAKs) are known to play a role in the regulation of cell morphology and functions. Among the various members of PAKs family, only the PAK4 protein has been shown to be overexpressed in cancer cells and its upregulation was associated with tumor development. Indeed, several studies have shown that PAK4 overexpression is implicated in carcinogenesis by different mechanisms including promotion of cell proliferation, invasion and migration, protection of cells from apoptosis, stimulation of the tumor-specific anchorage-independent cell growth and regulation of the cytoskeletal organisation and adhesion. Moreover, high PAK4 protein levels have been observed in several solid tumors and have been shown able to enhance cancer cell resistance to many treatments especially chemotherapy. Interestingly, it has been recently demonstrated that PAK4 downregulation can inhibit the PD-1/PD-L1 immune regulatory pathway. Taken together, these findings not only implicate PAK4 in oncogenic transformation and in prediction of tumor response to treatment but also suggest its role as an attractive target for immunotherapy. In the current review we will summarize the different mechanisms of PAK4 implication in tumor development, describe its role as a regulator of the immune response and as a potential novel target for cancer immunotherapy.

Other Information

Published in: Cellular Immunology
See article on publisher's website:


Open Access funding provided by the Qatar National Library



  • English



Publication Year

  • 2021

License statement

This Item is licensed under the Creative Commons Attribution 4.0 International License

Institution affiliated with

  • Hamad Medical Corporation
  • National Center for Cancer Care and Research - HMC
  • Academic Health System - HMC
  • Interim Translational Research Institute - HMC
  • Dermatology Institute - HMC
  • Qatar University
  • Qatar University Health - QU
  • College of Medicine - QU HEALTH
  • Hamad Bin Khalifa University
  • College of Health and Life Sciences - HBKU

Usage metrics

    National Center for Cancer Care and Research - HMC



    Ref. manager