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The quality of energy- and macronutrient-balanced diets regulates host susceptibility to influenza in mice

journal contribution
submitted on 2024-04-02, 09:14 and posted on 2024-04-02, 09:15 authored by Taylor A. Cootes, Nayan D. Bhattacharyya, Susie S.Y. Huang, Lina Daniel, Kim S. Bell-Anderson, Sebastian A. Stifter, Tracy Chew, Samantha M. Solon-Biet, Luis R. Saraiva, Yi Cai, Xinchun Chen, Stephen J. Simpson, Carl G. Feng

Modulation of individual macronutrients or caloric density is known to regulate host resistance to infection in mice. However, the impact of diet composition, independent of macronutrient and energy content, on infection susceptibility is unclear. We show that two laboratory rodent diets, widely used as standard animal feeds and experimental controls, display distinct abilities in supporting mice during influenza infection. Mice placed on the highly processed AIN93G showed increased mortality to infection compared with those on a grain-based chow diet, suggesting a detrimental role for highly processed food in host defense. We further demonstrate that the heightened susceptibility of AIN93G-fed mice was associated with the failure in homeostasis restoration mediated by the cytokine interferon (IFN)-γ. Our findings show that diet composition calibrates host survival threshold by regulating adaptive homeostasis and highlights a pivotal role for extrinsic signals in host phenotype and outcome of host-pathogen interaction.

Other Information

Published in: Cell Reports
See article on publisher's website:



  • English



Publication Year

  • 2022

License statement

This Item is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Institution affiliated with

  • Sidra Medicine
  • Hamad Bin Khalifa University
  • College of Health and Life Sciences - HBKU

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