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The impact of COVID-19 on “biological aging”

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submitted on 2024-07-23, 05:41 and posted on 2024-07-23, 08:58 authored by Fathima Humaira Amanullah, Tanvir Alam, Nady El Hajj, Yosra Bejaoui

The global impact of the SARS-CoV-2 pandemic has been unprecedented, posing a significant public health challenge. Chronological age has been identified as a key determinant for severe outcomes associated with SARS-CoV-2 infection. Epigenetic age acceleration has previously been observed in various diseases including human immunodeficiency virus (HIV), Cytomegalovirus (CMV), cardiovascular diseases, and cancer. However, a comprehensive review of this topic is still missing in the field. In this review, we explore and summarize the research work focusing on biological aging markers, i.e., epigenetic age and telomere attrition in COVID-19 patients. From the reviewed articles, we identified a consistent pattern of epigenetic age dysregulation and shortened telomere length, revealing the impact of COVID-19 on epigenetic aging and telomere attrition.

Other Information

Published in: Frontiers in Immunology
License: https://creativecommons.org/licenses/by/4.0/
See article on publisher's website: https://dx.doi.org/10.3389/fimmu.2024.1399676

Funding

Hamad Bin Khalifa University, College of Health and Life Sciences (N/A).

History

Language

  • English

Publisher

Frontiers

Publication Year

  • 2024

License statement

This Item is licensed under the Creative Commons Attribution 4.0 International License.

Institution affiliated with

  • Hamad Bin Khalifa University
  • College of Health and Life Sciences - HBKU
  • College of Science and Engineering - HBKU

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