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The 3Ds in virus‐like particle based‐vaccines: “Design, Delivery and Dynamics

journal contribution
submitted on 2024-07-07, 10:25 and posted on 2024-07-07, 10:26 authored by Mona O. Mohsen, Gilles Augusto, Martin F. Bachmann

Vaccines need to be rationally designed in order be delivered to the immune system for maximizing induction of dynamic immune responses. Virus‐like particles (VLPs) are ideal platforms for such 3D vaccines, as they allow the display of complex and native antigens in a highly repetitive form on their surface and can easily reach lymphoid organs in intact form for optimal activation of B and T cells. Adjusting size and zeta potential may allow investigators to further fine‐tune delivery to lymphoid organs. An additional way to alter vaccine transfer to lymph nodes and spleen may be the formulation with micron‐sized adjuvants that creates a local depot and results in a slow release of antigen and adjuvant. Ideally, the adjuvant in addition stimulates the innate immune system. The dynamics of the immune response may be further enhanced by inclusion of Toll‐like receptor ligands, which many VLPs naturally package. Hence, considering the 3Ds in vaccine development may allow for enhancement of their attributes to tackle complex diseases, not usually amenable to conventional vaccine strategies.

Other Information

Published in: Immunological Reviews
License: http://creativecommons.org/licenses/by/4.0/
See article on publisher's website: https://dx.doi.org/10.1111/imr.12863

Funding

Qatar National Research Fund (PDRA4‐0118‐18002), Development and exploration of a novel personalized breast-cancer vaccine based on virus-like particles by incorporating tumor- specific T-cell epitopes.

Schweizerische Arbeitsgemeinschaft für Klinische Krebsforschung (KFS‐4291‐08‐2017‐R).

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (CRSII3_154490).

History

Language

  • English

Publisher

Wiley

Publication Year

  • 2020

License statement

This Item is licensed under the Creative Commons Attribution 4.0 International License.

Institution affiliated with

  • Hamad Medical Corporation
  • National Center for Cancer Care and Research - HMC
  • Interim Translational Research Institute - HMC

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