The Regulation and Immune Signature of Retrotransposons in Cancer
Advances in sequencing technologies and the bioinformatic analysis of big data facilitate the study of jumping genes’ activity in the human genome in cancer from a broad perspective. Retrotransposons, which move from one genomic site to another by a copy-and-paste mechanism, are regulated by various molecular pathways that may be disrupted during tumorigenesis. Active retrotransposons can stimulate type I IFN responses. Although accumulated evidence suggests that retrotransposons can induce inflammation, the research investigating the exact mechanism of triggering these responses is ongoing. Understanding these mechanisms could improve the therapeutic management of cancer through the use of retrotransposon-induced inflammation as a tool to instigate immune responses to tumors.
Other Information
Published in: Cancers
License: https://creativecommons.org/licenses/by/4.0/
See article on publisher's website: https://dx.doi.org/10.3390/cancers15174340
Funding
Open Access funding provided by the Qatar National Library
History
Language
- English
Publisher
MDPIPublication Year
- 2023
License statement
This Item is licensed under the Creative Commons Attribution 4.0 International LicenseInstitution affiliated with
- Hamad Bin Khalifa University
- College of Health and Life Sciences - HBKU