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Synergistic Effects of Nanomedicine Targeting TNFR2 and DNA Demethylation Inhibitor—An Opportunity for Cancer Treatment

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submitted on 2024-05-13, 06:04 and posted on 2024-05-13, 06:04 authored by Mohammad A. I. Al-Hatamleh, Engku Nur Syafirah E.A.R., Jennifer C. Boer, Khalid Ferji, Jean-Luc Six, Xin Chen, Eyad Elkord, Magdalena Plebanski, Rohimah Mohamud

Tumor necrosis factor receptor 2 (TNFR2) is expressed on some tumor cells, such as myeloma, Hodgkin lymphoma, colon cancer and ovarian cancer, as well as immunosuppressive cells. There is increasingly evidence that TNFR2 expression in cancer microenvironment has significant implications in cancer progression, metastasis and immune evasion. Although nanomedicine has been extensively studied as a carrier of cancer immunotherapeutic agents, no study to date has investigated TNFR2-targeting nanomedicine in cancer treatment. From an epigenetic perspective, previous studies indicate that DNA demethylation might be responsible for high expressions of TNFR2 in cancer models. This perspective review discusses a novel therapeutic strategy based on nanomedicine that has the capacity to target TNFR2 along with inhibition of DNA demethylation. This approach may maximize the anti-cancer potential of nanomedicine-based immunotherapy and, consequently, markedly improve the outcomes of the management of patients with malignancy.

Other Information

Published in: Cells
License: https://creativecommons.org/licenses/by/4.0/
See article on publisher's website: https://dx.doi.org/10.3390/cells9010033

Funding

Fundamental Research Grant Scheme (FRGS) by Ministry of Higher Education (MOHE) Malaysia (203/PPSP/6171198).

Universiti Sains Malaysia (USM) Research Grant (1001/PPSP/8012294).

History

Language

  • English

Publisher

MDPI

Publication Year

  • 2019

License statement

This Item is licensed under the Creative Commons Attribution 4.0 International License.

Institution affiliated with

  • Hamad Bin Khalifa University
  • Qatar Biomedical Research Institute - HBKU
  • Cancer Research Center - QBRI

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