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Superior Non-Invasive Glucose Sensor Using Bimetallic CuNi Nanospecies Coated Mesoporous Carbon

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submitted on 2024-05-08, 12:05 and posted on 2024-05-08, 12:05 authored by Ahmed Bahgat Radwan, Sreedevi Paramparambath, John-John Cabibihan, Abdulaziz Khalid Al-Ali, Peter Kasak, Rana A. Shakoor, Rayaz A. Malik, Said A. Mansour, Kishor Kumar Sadasivuni

The assessment of blood glucose levels is necessary for the diagnosis and management of diabetes. The accurate quantification of serum or plasma glucose relies on enzymatic and nonenzymatic methods utilizing electrochemical biosensors. Current research efforts are focused on enhancing the non-invasive detection of glucose in sweat with accuracy, high sensitivity, and stability. In this work, nanostructured mesoporous carbon coupled with glucose oxidase (GOx) increased the direct electron transfer to the electrode surface. A mixed alloy of CuNi nanoparticle-coated mesoporous carbon (CuNi-MC) was synthesized using a hydrothermal process followed by annealing at 700 °C under the flow of argon gas. The prepared catalyst’s crystal structure and morphology were explored using X-ray diffraction and high-resolution transmission electron microscopy. The electrocatalytic activity of the as-prepared catalyst was investigated using cyclic voltammetry (CV) and amperometry. The findings show an excellent response time of 4 s and linear range detection from 0.005 to 0.45 mM with a high electrode sensitivity of 11.7 ± 0.061 mA mM cm−2 in a selective medium.

Other Information

Published in: Biosensors
License: https://creativecommons.org/licenses/by/4.0/
See article on publisher's website: https://dx.doi.org/10.3390/bios11110463

History

Language

  • English

Publisher

MDPI

Publication Year

  • 2021

License statement

This Item is licensed under the Creative Commons Attribution 4.0 International License.

Institution affiliated with

  • Qatar University
  • Center for Advanced Materials - QU
  • College of Engineering - QU
  • KINDI Center for Computing Research - CENG
  • Weill Cornell Medicine - Qatar
  • Hamad Bin Khalifa University
  • Qatar Environment and Energy Research Institute - HBKU

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