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10.1016_j.cellsig.2023.110904.pdf (3.89 MB)

Role of HMGB1 and its associated signaling pathways in human malignancies

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journal contribution
submitted on 2023-11-22, 10:01 and posted on 2023-11-22, 12:19 authored by Sourour Idoudi, Takwa Bedhiafi, Shona Pedersen, Mohamed Elahtem, Izzaldin Alremawi, Sabah Akhtar, Said Dermime, Maysaloun Merhi, Shahab Uddin

The High-Mobility Group Box-1 (HMGB1), a non-histone chromatin-associated protein, plays a crucial role in cancer growth and response to therapy as it retains a pivotal role in promoting both cell death and survival. HMGB1 has been reported to regulate several signaling pathways engaged in inflammation, genome stability, immune function, cell proliferation, cell autophagy, metabolism, and apoptosis. However, the association between HMGB1 and cancer is complex and its mechanism in tumorigenesis needs to be further elucidated. This review aims to understand the role of HMGB1 in human malignancies and discuss the signaling pathways linked to this process to provide a comprehensive understanding on the association of HMGB1 with carcinogenesis. Further, we will review the role of HMGB1 as a target/biomarker for cancer therapy, the therapeutic strategies used to target this protein, and its potential role in preventing or treating cancers. In light of the recent growing evidence linking HMGB1 to cancer progression, we think that it may be suggested as a novel and emergent therapeutic target for cancer therapy. Hence, HMGB1 warrants paramount investigation to comprehensively map its role in tumorigenesis.

Other Information

Published in: Cellular Signalling
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Additional institutions affiliated with: Education and Research - HMC, Qatar University Health - QU


Open Access funding provided by the Qatar National Library



  • English



Publication Year

  • 2023

License statement

This Item is licensed under the Creative Commons Attribution 4.0 International License.

Institution affiliated with

  • Hamad Medical Corporation
  • National Center for Cancer Care and Research - HMC
  • Interim Translational Research Institute - HMC
  • Dermatology Institute - HMC
  • Qatar University
  • Laboratory Animal Research Center - QU
  • College of Pharmacy - QU HEALTH
  • College of Medicine - QU HEALTH
  • Hamad Bin Khalifa University
  • College of Health and Life Sciences - HBKU