Manara - Qatar Research Repository
Browse
1-s2.0-S147148922030093X-main.pdf (1.63 MB)

Recent developments in unraveling signaling mechanisms underlying drug resistance due to cancer stem-like cells

Download (1.63 MB)
journal contribution
submitted on 2023-10-04, 06:25 and posted on 2023-10-04, 07:21 authored by Abdul Q Khan, Khalid Rashid, Abdulhadi A AlAmodi, Syed Shadab Raza, Shahab Uddin

Resistance in cancer cells to therapeutic measures is challenging and requires a rigorous delineation of the underlying mechanisms. Emerging findings reflect the characteristics of tumor cells to do the reprogramming of signaling machinery in order to overturn the therapeutic responses. Recent evidence shows that the tumor acquires drug resistance due to the presence of cancer stem cells (CSCs). Hence the understanding that how tumor cells reprogram their signaling mechanisms converging towards the stemness of CSCs is imperative for novel and effective therapy. This review outlines the current updates on how CSC-associated signaling pathways and its enhanced stemness trigger the development of drug resistance. Furthermore, we also discussed the strategies with a combinational approach that can simultaneously target both CSC-induced stemness and the resistance-related signaling pathways, which may provide an optimal outcome to overcome the problem of drug resistance in cancer therapy.

Other Information

Published in: Current Opinion in Pharmacology
License: http://creativecommons.org/licenses/by/4.0/
See article on publisher's website: https://dx.doi.org/10.1016/j.coph.2020.09.012

Funding

Open Access funding provided by the Qatar National Library

History

Language

  • English

Publisher

Elsevier BV

Publication Year

  • 2020

License statement

This Item is licensed under the Creative Commons Attribution 4.0 International License

Institution affiliated with

  • Hamad Medical Corporation
  • Academic Health System - HMC
  • Interim Translational Research Institute - HMC
  • Dermatology Institute - HMC
  • Rumailah Hospital - HMC

Usage metrics

    Hamad Medical Corporation

    Licence

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC