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Recent advances in stimuli-responsive drug release and targeting concepts using mesoporous silica nanoparticles

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posted on 2022-11-22, 21:16 authored by Ghada G. Abdo, Moustafa M. Zagho, Ashraf Khalil

Being a developed and promising approach, nanotechnology has attracted a lot of attention in biomedical and pharmaceutical therapy applications. Among nanostructured materials, mesoporous silica nanoparticles (MSNs) are effectively used as nanocarriers for drug delivery systems. MSNs can be tailored-designed by different synthetic techniques. Their morphological characteristics dictate the type of application of such materials. Recently, polymer-based materials have been employed to functionalize the MSNs surface. These modified nanocarriers are loaded with the drug and can unload their “cargo” upon exposure to either endogenous or exogenous types of stimuli. In this study, different targeting concepts, including passive, active, vascular, nuclear, and multistage targeting, are discussed.

Other Information

Published in: Emergent Materials
License: https://creativecommons.org/licenses/by/4.0
See article on publisher's website: http://dx.doi.org/10.1007/s42247-020-00109-x

History

Language

  • English

Publisher

Springer Science and Business Media LLC

Publication Year

  • 2020

Institution affiliated with

  • Qatar University

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