Manara - Qatar Research Repository
Browse
1-s2.0-S2468294222001460-main.pdf (669.02 kB)

Real-world clinical outcomes with daily image-guided IMRT in extremity soft tissue sarcomas

Download (669.02 kB)
journal contribution
submitted on 2023-11-08, 06:32 and posted on 2023-11-08, 07:43 authored by Venkada Manickam Gurusamy, Noora Al-Hammadi, Palmira Caparrotti, Saju Raveendran Divakar, Rabih Wafiq Hammoud, Ghazia Shaikh

Purpose

We report the clinical outcomes of patients with soft tissue sarcomas (STS) arising in extremities treated with image-guided intensity modulated radiotherapy (IG-IMRT) at our institute. Local control of the tumors treated with RT was the primary end point of this study. Analyzing overall survival and long-term toxicities were the secondary objectives.

Methods and materials

The database of the patients with STS who received wide local excision and IG-IMRT at our institution from January 2012 to December 2020 was reviewed. Radiation was offered either preoperatively or postoperatively as part of multi-modality treatment.

Results

Thirty-three consecutive patients were identified and included for analysis. Twenty-eight patients (84.8%) received postoperative adjuvant radiotherapy. Dedicated MRI simulation studies were performed in 31 patients (93.9%) in the treatment position. RapidArc IMRT technique was used in 31 patients (93.9%). A total of 2954 images were acquired during 991 treatment sessions. Errors exceeding 1 mm in the x, y and z directions were corrected online before the treatment. With a median follow-up of 36 months, two patients (6.1%) developed local recurrence. The 3-year local control was 90.9% (95% CI, 0.76 - 0.98), and the 5-year overall survival was 71.7% (95% CI, 0.44 – 0.88). One patient (3.03%) sustained a pathological fracture during the follow-up period.

Conclusion

Our results showed that IMRT with daily imaging offered excellent local control with acceptable long-term toxicity, as well as being feasible and practical to implement in our routine clinical practice.

Other Information

Published in: Cancer Treatment and Research Communications
License: http://creativecommons.org/licenses/by/4.0/
See article on publisher's website: https://dx.doi.org/10.1016/j.ctarc.2022.100655

Funding

Open Access funding provided by the Qatar National Library

History

Language

  • English

Publisher

Elsevier

Publication Year

  • 2022

License statement

This Item is licensed under the Creative Commons Attribution 4.0 International License

Institution affiliated with

  • Hamad Medical Corporation
  • National Center for Cancer Care and Research - HMC

Usage metrics

    National Center for Cancer Care and Research - HMC

    Licence

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC