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Neurobrucellosis complicated by primary pyogenic ventriculitis: a case report

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submitted on 2024-02-11, 11:17 and posted on 2024-02-11, 11:17 authored by Mohammed Alhatou, Anwar I Joudeh, Abraham Alhatou, Mohamed Ghamoodi

Neurobrucellosis is a serious focal brucella infection. Ventriculitis is a special form of central nervous infection where pyogenic infection of the ependymal linings hinders antibiotics’ accessibility to the cerebrospinal fluids and leads to protracted infection. We present a case of a 37-year-old Shepherd who had low-grade fever for 5 months followed by a brief history of vomiting, abdominal pain, and gait imbalance. Investigations showed neutrophilic leukocytosis, high titers of serum anti-brucella antibodies, and lymphocytic pleocytosis. Mycobacterial tuberculosis workup was negative. Magnetic resonance imaging of the brain revealed cervical and spinal meningeal enhancement in addition to mild hydrocephalus. The patient was presumptively diagnosed with neurobrucellosis. He received treatment with ceftriaxone-based combination antibiotics therapy for 6 months with complete resolution of his symptoms. Central nervous infection by brucella is a challenging diagnosis. The possibility of primary ventriculitis due to Brucella infection mandates early recognition and prolonged antimicrobial therapy to achieve full recovery.

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Published in: Oxford Medical Case Reports
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Open Access funding provided by the Qatar National Library.



  • English


Oxford University Press

Publication Year

  • 2024

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This Item is licensed under the Creative Commons Attribution-NonCommercial 4.0 International License

Institution affiliated with

  • Hamad Medical Corporation
  • Al Khor Hospital - HMC

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