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Natural resorcylic acid lactones: A chemical biology approach for anticancer activity

journal contribution
submitted on 2023-10-19, 04:38 and posted on 2023-10-19, 08:00 authored by Shilpa Kuttikrishnan, Kirti S. Prabhu, Ahmed H. Al Sharie, Yazan O. Al Zu'bi, Feras Q. Alali, Nicholas H. Oberlies, Aamir Ahmad, Tamam El-Elimat, Shahab Uddin

Resorcylic acid lactones (RALs) are fungal polyketides that consist of a β-resorcylic acid residue (2,4-dihydroxybenzoic acid) embedded in a macrolactone ring. RALs exhibit a broad range of biological activities, including anticancer activities. Following discovery of the selective Hsp90 inhibition activity of radicicol, the kinase inhibition activity of hypothemycin, monocillin II, 5Z-7-oxo-zeaenol, and L-783,277 RALs, and the nuclear factor kappa B (NF-κB) inhibition activity of the RAL zearalenone, have attracted great attention as potential therapeutics for cancer treatment. In this minireview, we focus on natural RALs that possess cytotoxic activities [IC50 values < 10 μM (or 4–5 μg/ml)], discussing their structures, isolation, occurrence, biological activities, and anticancer molecular mechanisms.

Other Information

Published in: Drug Discovery Today
License: http://creativecommons.org/licenses/by/4.0/
See article on publisher's website: https://dx.doi.org/10.1016/j.drudis.2021.10.001

Funding

Open Access funding provided by the Qatar National Library

History

Language

  • English

Publisher

Elsevier

Publication Year

  • 2022

License statement

This Item is licensed under the Creative Commons Attribution 4.0 International License

Institution affiliated with

  • Hamad Medical Corporation
  • Interim Translational Research Institute - HMC
  • Academic Health System - HMC
  • Dermatology Institute - HMC
  • Qatar University
  • Laboratory Animal Research Center - QU
  • Qatar University Health - QU
  • Biomedical and Pharmaceutical Research Unit - QU HEALTH
  • College of Pharmacy - QU HEALTH