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Nano-vitamin C: A promising candidate for therapeutic applications

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journal contribution
submitted on 2023-11-05, 11:05 and posted on 2023-11-05, 11:15 authored by Takwa Bedhiafi, Sourour Idoudi, Queenie Fernandes, Lobna Al-Zaidan, Shahab Uddin, Said Dermime, Nashiru Billa, Maysaloun Merhi

Vitamin C is an important nutrient implicated in different physiological functions in humans. Despite its important biological functions, therapeutic applications of vitamin C are rare and its use is further impacted by low chemical stability. Several nano-encapsulation techniques have been described in the literature and yet, there are only a handful of clinical investigations dedicated to unlocking the therapeutic applications of nano-encapsulated vitamin C. Clearly, further investigations are warranted in order to affirm the promising clinical potential of nano-encapsulated vitamin C. In this review, we describe the mechanisms of vitamin C activity as a modulator of crucial therapeutic uses in biological systems. We look at key factors affecting the chemical stability of vitamin C alone and in nano-encapsulated and explore pre-clinical and clinical evidence on current vitamin C nano-formulations along with their therapeutic applications. Finally, we critically appraise the gaps and opportunities prevailing in nano-vitamin C research and its potential translation towards relevant clinical outcomes.

Other Information

Published in: Biomedicine & Pharmacotherapy
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Open Access funding provided by the Qatar National Library



  • English



Publication Year

  • 2023

License statement

This Item is licensed under the Creative Commons Attribution 4.0 International License

Institution affiliated with

  • Hamad Medical Corporation
  • Interim Translational Research Institute - HMC
  • National Center for Cancer Care and Research - HMC
  • Qatar University
  • Laboratory Animal Research Center - QU
  • Qatar University Health - QU
  • College of Pharmacy - QU HEALTH
  • College of Medicine - QU HEALTH
  • Hamad Bin Khalifa University
  • College of Health and Life Sciences - HBKU

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