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Mechanosensitive Pathways in Heart Development: Findings from Chick Embryo Studies

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journal contribution
submitted on 2024-05-14, 05:33 and posted on 2024-05-14, 05:33 authored by Maha Alser, Samar Shurbaji, Huseyin C. Yalcin

The heart is the first organ that starts to function in a developing embryo. It continues to undergo dramatic morphological changes while pumping blood to the rest of the body. Genetic regulation of heart development is partly governed by hemodynamics. Chick embryo is a major animal model that has been used extensively in cardiogenesis research. To reveal mechanosensitive pathways, a variety of surgical interferences and chemical treatments can be applied to the chick embryo to manipulate the blood flow. Such manipulations alter expressions of mechanosensitive genes which may anticipate induction of morphological changes in the developing heart. This paper aims to present different approaches for generating clinically relevant disturbed hemodynamics conditions using this embryonic chick model and to summarize identified mechanosensitive genes using the model, providing insights into embryonic origins of congenital heart defects.

Other Information

Published in: Journal of Cardiovascular Development and Disease
See article on publisher's website:



  • English



Publication Year

  • 2021

License statement

This Item is licensed under the Creative Commons Attribution 4.0 International License.

Institution affiliated with

  • Qatar University
  • Biomedical Research Center - QU
  • Hamad Bin Khalifa University
  • College of Health and Life Sciences - HBKU