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Lipid profile in Parkinson's disease: The potential role of brain-derived neurotrophic factor

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submitted on 2023-11-07, 07:16 and posted on 2023-11-07, 12:43 authored by Mahmoud A. Alomari, Hanan Khalil, Omar F. Khabour, Karem H. Alzoubi

Background

Parkinson's disease is a neurodegenerative disease manifested as increased tremor, bradykinesia, rigidity, and postural instability. Brain-derived neurotrophic factor (BDNF) is essential for neurocognitive function. However, its cardiometabolic effect has recently been identified in health and disease, but not in PD. Therefore, the current study examined the relationship of BDNF with glucose and lipid profile.

Methods

This was a cross sectional comparative study where PD patients (n = 26) and age-matched healthy controls (n = 27) were recruited. Blood samples were drawn to determine BDNF, glucose, and lipid profile including total cholesterol (TC), HDL, LDL, triglyceride (TriG).

Result

The linear regression showed that BDNF predicted 11.9 % of TC (p = 0.05), 3.0 % of HDL (p = 0.003), 27.3 % of LDL (p = 0.006), 16.6 % of TriG (p = 0.04), 15.8 % of TC/HDL (p = 0.06), 22.1 % of TC/LDL (p = 0.01), and 35.1 % of TriG/HDL (p = 0.001) but not glucose (B = -0.006; CI = -0.19/0.18; F = 0.005; p = 0.9) and LDL/HDL (B = 0.06; CI = -0.17/0.3; F = 0.3; p = 0.6). Subsequent ANCOVA revealed differences (p < 0.05) in TC, HDL, LDL, TC/LDL, and TriG/HDL but not in glucose, TriG, and TC/HDL among the patients with low-BDNF versus high-BDNF.

Significance

The results demonstrate a relationship of BDNF with lipid profile suggesting the importance of BDNF for lipid metabolism in PD.

Other Information

Published in: Life Sciences
License: http://creativecommons.org/licenses/by/4.0/
See article on publisher's website: https://dx.doi.org/10.1016/j.lfs.2022.121144

Funding

Open Access funding provided by the Qatar National Library

History

Language

  • English

Publisher

Elsevier

Publication Year

  • 2022

License statement

This Item is licensed under the Creative Commons Attribution 4.0 International License

Institution affiliated with

  • Qatar University
  • Qatar University Health - QU
  • College of Health Sciences - QU HEALTH

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