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Isolated pulmonary cryptococcosis in a patient with Crohn's disease treated with infliximab: A case report and literature review

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submitted on 2023-10-29, 05:49 and posted on 2023-10-29, 10:30 authored by Mousa Hussein, Irfan Ul Haq, Mansoor Hameed, Abbas Alabbas, Hamad Abdel Hadi, Anam Elarabi, Issam Al-Bozom

Tumor necrosis factor-alpha (TNF-α) inhibitors are widely used to treat various inflammatory conditions, where they have demonstrated excellent efficacy and tolerability. However, increased risk of infections is one of the most important concerns associated with these agents. Reactivation of tuberculosis and fungal infections have emerged as significant infective complications of anti-TNF-α therapy. Cryptococcus infection is an opportunistic fungal infection that can occur in patients receiving anti-TNF-α treatment. We report a rare case of isolated pulmonary cryptococcosis in a patient undergoing anti-TNF-α therapy for Crohn's disease. Our case should alert clinicians to the increased incidence and atypical presentation of pulmonary cryptococcosis in patients receiving anti-TNF-α treatment.

Other Information

Published in: Respiratory Medicine Case Reports
License: http://creativecommons.org/licenses/by/4.0/
See article on publisher's website: https://dx.doi.org/10.1016/j.rmcr.2021.101459

Funding

Open Access funding provided by the Qatar National Library

History

Language

  • English

Publisher

Elsevier

Publication Year

  • 2021

License statement

This Item is licensed under the Creative Commons Attribution 4.0 International License

Institution affiliated with

  • Hamad Medical Corporation

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    Hamad Medical Corporation

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