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Internalization of Metal–Organic Framework Nanoparticles in Human Vascular Cells: Implications for Cardiovascular Disease Therapy

Version 2 2024-05-27, 05:03
Version 1 2023-06-18, 12:41
journal contribution
revised on 2024-05-27, 05:02 and posted on 2024-05-27, 05:03 authored by Dana E. Al-Ansari, Nura A. Mohamed, Isra Marei, Atef Zekri, Yu Kameno, Robert P. Davies, Paul D. Lickiss, Md Mizanur Rahman, Haissam Abou-Saleh

Cardiovascular diseases (CVDs) are the leading cause of morbidity and mortality worldwide. Alteration of endothelial cells and the underlying vasculature plays a central role in the pathogenesis of various CVDs. The application of nanoscale materials such as nanoparticles in biomedicine has opened new horizons in the treatment of CVDs. We have previously shown that the iron metal–organic framework nanoparticle, Materials Institut Lavoisier-89 (nanoMIL-89) represents a viable vehicle for future drug delivery of pulmonary arterial hypertension. In this study, we have assessed the cellular uptake of nanoMIL-89 in pulmonary artery endothelial and smooth muscle cells using microscopy imaging techniques. We also tested the cellular responses to nanoMIL-89 using molecular and cellular assays. Microscopic images showed cellular internalization of nanoMIL-89, packaging into endocytic vesicles, and passing to daughter cells during mitosis. Moreover, nanoMIL-89 showed anti-inflammatory activity without any significant cytotoxicity. Our results indicate that nanoMIL-89 formulation may offer promising therapeutic opportunities and set forth a new prototype for drug delivery not only in CVDs, but also for other diseases yet incurable, such as diabetes and cancer.

Other Information

Published in: Nanomaterials
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Open Access funding provided by the Qatar National Library

This work was supported by the UREP grant [22-140-3-023] from Qatar National Research Fund (QNRF), a member of Qatar Foundation and the Pickford Award from the British Pharmacological Society (awarded to NAM), who we would like to acknowledge for their generous support.

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  • English



Publication Year

  • 2020

License statement

This Item is licensed under the Creative Commons Attribution 4.0 International License.

Institution affiliated with

  • Qatar University
  • College of Arts and Sciences - QU
  • Qatar University Health - QU
  • Biomedical Research Center - QU
  • Weill Cornell Medicine - Qatar
  • Hamad Bin Khalifa University
  • Qatar Environment and Energy Research Institute - HBKU