Manara - Qatar Research Repository
Browse
10.1080_13685538.2019.1692198.pdf (914.93 kB)

Incidence and clinical outcome of Cryptococcosis in a nation with advanced HIV surveillance program

Download (914.93 kB)
journal contribution
submitted on 2024-03-13, 08:02 and posted on 2024-03-13, 08:03 authored by Fatma Ben Abid, Hussam Abdel Rahman S. Al Soub, Muna Al Maslamani, Wanis Hamad Ibrahim, Hafedh Ghazouani, Abdullatif Al-Khal, Saad Taj-Aldeen

Background

Cryptococcosis is a major opportunistic invasive mycosis that mostly affects immunocompromised patients.


Methods

This was an observational study of all culture-confirmed cases of cryptococcosis conducted in the State of Qatar from January 2005 to December 2016. Cryptococcus fungi were identified using Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry (MALDI-TOF MS).


Results

Fourteen culture-confirmed cases of cryptococcosis were identified during the study period. Four patients had a Human Immunodeficiency Virus (HIV) infection with low CD4 count and five were receiving immunosuppressant medications. The rest of the patients were apparently immuno-competent. The central nervous system was the most common site of infection (57%) followed by bloodstream infection (36%) and pneumonia (14%). One patient had a cryptococcal scrotal infection. Twelve isolates were Cryptococcus neoformans and 2 were Cryptococcus laurentii. All isolates were within the wild type ECV values to amphotericin B and fluconazole. Only 2 patients with bloodstream infection (HIV negative) died. The rest were cured of the infection.


Conclusion

Cryptococcosis is a rare fungal disease in the State of Qatar, mostly diagnosed in Asian immigrants. The central nervous system is the most common site of infection. The presence of the fungus in the blood carries a high mortality.

Other Information

Published in: The Aging Male
License: http://creativecommons.org/licenses/by-nc-nd/4.0/
See article on publisher's website: https://dx.doi.org/10.1080/13685538.2019.1692198

Funding

Open Access funding provided by the Qatar National Library.

History

Language

  • English

Publisher

Taylor & Francis

Publication Year

  • 2019

License statement

This Item is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Institution affiliated with

  • Hamad Medical Corporation
  • Hamad General Hospital - HMC
  • Communicable Disease Center - HMC

Usage metrics

    Hamad Medical Corporation

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC