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10.1016_j.ijregi.2021.12.005.pdf (527.88 kB)

Human herpes simplex virus-6 (HHV-6) detection and seroprevalence among Qatari nationals and immigrants residing in Qatar

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journal contribution
submitted on 2024-04-16, 08:53 and posted on 2024-04-16, 08:54 authored by Duaa W. Al-Sadeq, Hadeel T. Zedan, Nader Aldewik, Alaa Elkhider, Asalet Hicazi, Nadin Younes, Houssein H. Ayoub, Laith Abu Raddad, Hadi M. Yassine, Gheyath K. Nasrallah


Human herpes simplex virus-6 (HHV-6) is the causative agent of exanthema subitum. Transmission mainly occurs through salivary secretions, yet blood transfusions and organ transplantations have also been reported as routes of transmission. Studies of seroprevalence of HHV-6 in the Middle East and North Africa (MENA) region and other parts of Asia are scarce. As such, this study aimed to estimate the seroprevalence of HHV-6 among healthy blood donors in Qatar.


In total, 620 healthy blood donors from different nationalities residing in Qatar, mainly from the MENA region and Southeast Asia, were tested using a commercial anti-HHV-6 immunoglobulin G (IgG) enzyme-linked immunosorbent assay kit. In addition, HHV-6 DNA from randomly selected samples was tested and quantified using quantitative reverse transcriptase polymerase chain reaction.


Anti-HHV-6 IgG was detected in 71.7% (445/620) [95% confidence interval (CI) 68.2–75.3%] of the tested samples, while 24.3% (61/251) (95% CI 20.0–29.6%) had detectable HHV-6 viraemia. Only 22.5% of individuals with positive IgG status had detectable HHV-6 DNA in their blood, indicating a weak association between viraemia and IgG positivity (P=0.08). Furthermore, no significant difference was associated between HHV-6 viraemia and demographic characteristics, except for nationality.


The seroprevalence of HHV-6 in Qatar was found to be similar to rates reported in other parts of the world.

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Published in: IJID Regions
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Additional institutions affiliated with: Hamad Bin Khalifa University - college of Health and Life Science, Qatar University - College of Arts and Sciences, Weill Cornell Medicine - Qatar



  • English



Publication Year

  • 2022

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This Item is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Institution affiliated with

  • Qatar University
  • Qatar University Health - QU
  • Biomedical Research Center - QU
  • College of Medicine - QU HEALTH
  • College of Health Sciences - QU HEALTH
  • Hamad Medical Corporation
  • Hamad General Hospital - HMC
  • Women's Wellness and Research Center - HMC
  • Interim Translational Research Institute - HMC
  • Hamad Bin Khalifa University

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