10.1186_s12967-021-02797-3.pdf (827.14 kB)
Glucose excursions in type 2 diabetes modulate amyloid-related proteins associated with dementia
journal contribution
submitted on 2024-05-07, 06:15 and posted on 2024-05-07, 06:15 authored by Abu Saleh Md Moin, Ahmed Al-Qaissi, Thozhukat Sathyapalan, Stephen L. Atkin, Alexandra E. ButlerWe have reported that hypoglycemia was associated with changes in Alzheimer’s disease (AD)-related proteins in accord with the direct link of cognitive dysfunction to hypoglycemia. Dementia is a recognized complication of type 2 diabetes (T2D) with an increasing prevalence, and AD is the most common cause. However, whilst the stress induced by hypoglycemia was likely the trigger, the contribution of the fall in glucose alone was unclear, given that glucose variability is associated with lower level cognitive function.
Other Information
Published in: Journal of Translational Medicine
License: https://creativecommons.org/licenses/by/4.0
See article on publisher's website: https://dx.doi.org/10.1186/s12967-021-02797-3
History
Language
- English
Publisher
Springer NaturePublication Year
- 2021
License statement
This Item is licensed under the Creative Commons Attribution 4.0 International License.Institution affiliated with
- Hamad Bin Khalifa University
- Qatar Biomedical Research Institute - HBKU
- Diabetes Research Center - QBRI
