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Genome-Wide Association Study Reveals a Novel Association Between MYBPC3 Gene Polymorphism, Endurance Athlete Status, Aerobic Capacity and Steroid Metabolism

journal contribution
submitted on 2024-07-08, 06:50 and posted on 2024-07-14, 13:16 authored by Fatima Al-Khelaifi, Noha A. Yousri, Ilhame Diboun, Ekaterina A. Semenova, Elena S. Kostryukova, Nikolay A. Kulemin, Oleg V. Borisov, Liliya B. Andryushchenko, Andrey K. Larin, Edward V. Generozov, Eri Miyamoto-Mikami, Haruka Murakami, Hirofumi Zempo, Motohiko Miyachi, Mizuki Takaragawa, Hiroshi Kumagai, Hisashi Naito, Noriyuki Fuku, David Abraham, Aroon Hingorani, Francesco Donati, Francesco Botrè, Costas Georgakopoulos, Karsten Suhre, Ildus I. Ahmetov, Omar Albagha, Mohamed A. Elrayess

Background

The genetic predisposition to elite athletic performance has been a controversial subject due to the underpowered studies and the small effect size of identified genetic variants. The aims of this study were to investigate the association of common single-nucleotide polymorphisms (SNPs) with endurance athlete status in a large cohort of elite European athletes using GWAS approach, followed by replication studies in Russian and Japanese elite athletes and functional validation using metabolomics analysis.

Results

The association of 476,728 SNPs of Illumina DrugCore Gene chip and endurance athlete status was investigated in 796 European international-level athletes (645 males, 151 females) by comparing allelic frequencies between athletes specialized in sports with high (n = 662) and low/moderate (n = 134) aerobic component. Replication of results was performed by comparing the frequencies of the most significant SNPs between 242 and 168 elite Russian high and low/moderate aerobic athletes, respectively, and between 60 elite Japanese endurance athletes and 406 controls. A meta-analysis has identified rs1052373 (GG homozygotes) in Myosin Binding Protein (MYBPC3; implicated in cardiac hypertrophic myopathy) gene to be associated with endurance athlete status (P = 1.43 × 10−8, odd ratio 2.2). Homozygotes carriers of rs1052373 G allele in Russian athletes had significantly greater VO2max than carriers of the AA + AG (P = 0.005). Subsequent metabolomics analysis revealed several amino acids and lipids associated with rs1052373 G allele (1.82 × 10–05) including the testosterone precursor androstenediol (3beta,17beta) disulfate.

Conclusions

This is the first report of genome-wide significant SNP and related metabolites associated with elite athlete status. Further investigations of the functional relevance of the identified SNPs and metabolites in relation to enhanced athletic performance are warranted.

Other Information

Published in: Frontiers in Genetics
License: https://creativecommons.org/licenses/by/4.0/
See article on publisher's website: https://dx.doi.org/10.3389/fgene.2020.00595

Funding

Qatar National Research Fund (NPRP 7-272-1-04), Super athletes: Genes and Sweat.

History

Language

  • English

Publisher

Frontiers

Publication Year

  • 2020

License statement

This Item is licensed under the Creative Commons Attribution 4.0 International License.

Institution affiliated with

  • Hamad Bin Khalifa University
  • College of Health and Life Sciences - HBKU
  • Qatar University
  • Anti-Doping Laboratory Qatar
  • Biomedical Research Center - QU
  • Weill Cornell Medicine - Qatar

Related Datasets

Elrayess, Mohamed (2020). GWAS elite endurance athletes. figshare. Dataset. https://doi.org/10.6084/m9.figshare.12199760.v1 European Molecular Biology Laboratory (2024). GWAS Catalog : The NHGRI-EBI Catalog of human genome-wide association studies. https://www.ebi.ac.uk/gwas/downloads/summary-statistics

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