Manara - Qatar Research Repository
Browse

Gender Differences in Ghrelin Association with Cardiometabolic Risk Factors in Arab Population

Download (608.11 kB)
Version 2 2024-09-01, 06:30
Version 1 2024-09-01, 06:28
journal contribution
revised on 2024-09-01, 06:29 and posted on 2024-09-01, 06:30 authored by Mohamed Abu-Farha, Mohammed Dehbi, Fiona Noronha, Ali Tiss, Monira Alarouj, Kazem Behbehani, Abdullah Bennakhi, Naser Elkum

Ghrelin is a stomach produced hormone that has been shown to have protective role against development of CVD which is a leading cause of death in the Arab world. The objective of this study is to examine the gender difference in association between traditional CVD risk factors and plasma ghrelin among Arabs. 359 Arab residents in Kuwait participated in a cross-sectional survey (≥20 years old): 191 were females and 168 were males. Plasma level of ghrelin was assessed using Luminex-based assay. Ghrelin levels were significantly higher in females (935 ± 78 pg/mL) than males (763 ± 65 pg/mL) (P=0.0007). Females showed inverse association with WC (r=-0.23,P=0.001) and HbA1C (r=-0.19,P=0.0102) as well as SBP (r=-0.15,P=0.0383) and DBP (r=-0.16,P=0.0230), respectively. Higher levels of ghrelin were shown to associate with increased insulin resistance, as measured by HOMAIR, in male Arab subjects (P-trend = 0.0202) but not in females. In this study we show that higher ghrelin level was negatively associated with measures of obesity, HbA1C, and blood pressure in females and positively associated with increased insulin resistance in Arab males.

Other Information

Published in: International Journal of Endocrinology
License: https://creativecommons.org/licenses/by/3.0/
See article on publisher's website: https://dx.doi.org/10.1155/2014/730472

Funding

Kuwait Foundation for the Advancement of Sciences (RA-2010-004).

History

Language

  • English

Publisher

Hindawi

Publication Year

  • 2014

License statement

This Item is licensed under the Creative Commons Attribution 3.0 Unported License.

Institution affiliated with

  • Hamad Bin Khalifa University
  • Qatar Biomedical Research Institute - HBKU
  • Diabetes Research Center - QBRI
  • Sidra Medical and Research Center (2015-2017)
  • Sidra Medicine

Geographic coverage

Middle East and North Africa (MENA) and the Gulf Cooperation Council (GCC)