Manara - Qatar Research Repository
Browse
cancers-13-01576-v2.pdf (10.28 MB)

Flavonoids Alleviate Peripheral Neuropathy Induced by Anticancer Drugs

Download (10.28 MB)
journal contribution
submitted on 2024-07-01, 11:34 and posted on 2024-07-01, 11:34 authored by Manaal Siddiqui, Basma Abdellatif, Kevin Zhai, Alena Liskova, Peter Kubatka, Dietrich Büsselberg

Purpose: This study aimed to assess the potential of flavonoids in combating CIPN. Methods: PubMed and Google Scholar were used, and studies that investigated flavonoids in models of CIPN and models of neuropathic pain similar to CIPN were included. Only studies investigating peripheral mechanisms of CIPN were used. Results: Flavonoids inhibit several essential mechanisms of CIPN, such as proinflammatory cytokine release, astrocyte and microglial activation, oxidative stress, neuronal damage and apoptosis, mitochondrial damage, ectopic discharge, and ion channel activation. They decreased the severity of certain CIPN symptoms, such as thermal hyperalgesia and mechanical, tactile, and cold allodynia. Conclusions: Flavonoids hold immense promise in treating CIPN; thus, future research should investigate their effects in humans. Specifically, precise pharmacological mechanisms and side effects need to be elucidated in human models before clinical benefits can be achieved.

Other Information

Published in: Cancers
License: https://creativecommons.org/licenses/by/4.0/
See article on publisher's website: https://dx.doi.org/10.3390/cancers13071576

Funding

Qatar National Research Fund (NPRP11S-1214-170101), Anti-diabetic drugs in the treatment of breast cancer - identifying the molecular mechanism(s) and key biomarker(s).

Weill Cornell Medicine - Qatar, Distributed eLibrary - WCM-Q 2015-2022 (N/A).

History

Language

  • English

Publisher

MDPI

Publication Year

  • 2021

License statement

This Item is licensed under the Creative Commons Attribution 4.0 International License.

Institution affiliated with

  • Weill Cornell Medicine - Qatar