Fatty acid synthase: A key driver of ovarian cancer metastasis and a promising therapeutic target

<p dir="ltr"><u>Fatty acid synthase</u> (FASN) is a critical <u>enzyme</u> essential for the production of fats in the body. The abnormal expression of FASN is associated with different types of <u>malignancies</u>, including <u>ovarian cancer</u>. FASN plays a crucial role in cell growth and survival as a metabolic <u>oncogene</u>, although the specific processes that cause its dysregulation are still unknown. FASN interacts with <u>signaling pathways</u> linked to the progression of cancer. Pharmacologically inhibiting or inactivating the FASN gene has shown potential in causing the death of<u> cancer cells</u>, offering a possible treatment approach. This review examines the function of FASN in ovarian cancer, namely its level of expression, influence on the advancement of the disease, and its potential as a target for therapeutic interventions.</p><h2>Other Information</h2><p dir="ltr">Published in: Pathology - Research and Practice<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.prp.2024.155465" target="_blank">https://dx.doi.org/10.1016/j.prp.2024.155465</a></p>