Exosomes: Biological Carriers and Promising Tools for Cancer Immunotherapy

Exosomes are recognized as new therapeutic targets for cancer biomedicine and cancer immunotherapy [1]. More recently, emerging roles of exosomes as promising diagnostic tools and predictive biomarkers for cancer immunotherapy have been reported. Structurally, exosomes are small extracellular vesicles with 30 to 150 nm diameter, originate from one cell type (donor cell) and act as biological carriers [1]. They mediate cell-to-cell communication and exert biological activities by delivering their cargo contents, such as DNA, RNA, proteins or specific drugs, into target or recipient cells [2,3]. Exosomes are secreted from various cell types, including tumor and immune cells, and are capable of modifying the pathophysiological condition of recipient cells to convey messages which regulate distinct biological functions and transduce intercellular signaling [4].

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Published in: Vaccines
License: https://creativecommons.org/licenses/by/4.0/
See article on publisher's website: https://dx.doi.org/10.3390/vaccines8030390