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10.1016_j.semcancer.2023.04.005.pdf (1.36 MB)

Epigenetic programing of cancer stemness by transcription factors-non-coding RNAs interactions

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journal contribution
submitted on 2024-01-31, 09:16 and posted on 2024-01-31, 09:17 authored by Reem Khaled M.E. Alsayed, Khalid Sultan A.M. Sheikhan, Majid Ali Alam, Jorg Buddenkotte, Martin Steinhoff, Shahab Uddin, Aamir Ahmad

Cancer ‘stemness’ is fundamental to cancer existence. It defines the ability of cancer cells to indefinitely perpetuate as well as differentiate. Cancer stem cell populations within a growing tumor also help evade the inhibitory effects of chemo- as well as radiation-therapies, in addition to playing an important role in cancer metastases. NF-κB and STAT-3 are representative transcription factors (TFs) that have long been associated with cancer stemness, thus presenting as attractive targets for cancer therapy. The growing interest in non-coding RNAs (ncRNAs) in the recent years has provided further insight into the mechanisms by which TFs influence cancer stem cell characteristics. There is evidence for a direct regulation of TFs by ncRNAs, such as, microRNAs (miRNAs), long non-coding RNAs (lncRNAs) as well as circular RNAs (circRNAs), and vice versa. Additionally, the TF-ncRNAs regulations are often indirect, involving ncRNA-target genes or the sponging of other ncRNA species by individual ncRNAs. The information is rapidly evolving and this review provides a comprehensive review of TF-ncRNAs interactions with implications on cancer stemness and in response to therapies. Such knowledge will help uncover the many levels of tight regulations that control cancer stemness, providing novel opportunities and targets for therapy in the process.

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Published in: Seminars in Cancer Biology
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Open Access funding provided by the Qatar National Library.



  • English



Publication Year

  • 2023

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This Item is licensed under the Creative Commons Attribution 4.0 International License.

Institution affiliated with

  • Hamad Medical Corporation
  • Interim Translational Research Institute - HMC
  • Dermatology Institute - HMC
  • Rumailah Hospital - HMC
  • Weill Cornell Medicine - Qatar
  • Qatar University
  • Laboratory Animal Research Center - QU

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