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Epigenetic m6A RNA Modification Reader YTHDF1 in Merkel Cell Carcinoma

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journal contribution
submitted on 2024-08-25, 05:07 and posted on 2024-08-25, 05:08 authored by Aayami Jaguri, Martin Steinhoff, Aamir Ahmad

Merkel cell carcinoma (MCC) is a rare and aggressive neuroendocrine cutaneous malignancy that commonly affects older individuals with a high mortality rate. The treatment of MCC is still a challenge. The presence of Merkel cell polyomavirus (MCPyV or MCV) is a major causative factor for the disease, associated with approximately 80% of MCC cases. The only known polyomavirus virus to play a role in tumorigenesis, MCPyV, is a double-stranded DNA virus from the Polyomaviridae family of viruses and is known to target dermal fibroblasts. It induces oncogenesis by clonally integrating into the MCC tumor cell genome and expressing its oncogenic T antigens: large T (lT), small T (sT), and 57 kT antigens.

Other Information

Published in: Cancers
License: https://creativecommons.org/licenses/by/4.0/
See article on publisher's website: https://dx.doi.org/10.3390/cancers15164075

History

Language

  • English

Publisher

MDPI

Publication Year

  • 2023

License statement

This Item is licensed under the Creative Commons Attribution 4.0 International License.

Institution affiliated with

  • Hamad Bin Khalifa University
  • College of Health and Life Sciences - HBKU
  • Hamad Medical Corporation
  • Hamad General Hospital - HMC
  • Rumailah Hospital - HMC
  • Qatar University
  • Qatar University Health - QU
  • College of Medicine - QU HEALTH
  • Weill Cornell Medicine - Qatar