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Epigenetic and breast cancer therapy: Promising diagnostic and therapeutic applications

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submitted on 2023-09-28, 09:31 and posted on 2023-09-28, 12:49 authored by Gulab Sher, Nadia Aziz Salman, Abdul Q. Khan, Kirti S. Prabhu, Afsheen Raza, Michal Kulinski, Said Dermime, Mohammad Haris, Kulsoom Junejo, Shahab Uddin

The global burden of breast cancer (BC) is increasing significantly. This trend is caused by several factors such as late diagnosis, limited treatment options for certain BC subtypes, drug resistance which all lead to poor clinical outcomes. Recent research has reported the role of epigenetic alterations in the mechanism of BC pathogenesis and its hallmarks include drug resistance and stemness features. The understanding of these modifications and their significance in the management of BC carcinogenesis is challenging and requires further attention. Nevertheless, it promises to provide novel insight needed for utilizing these alterations as potential diagnostic, prognostic markers, predict treatment efficacy, as well as therapeutic agents. This highlights the importance of continuing research development to further advance the existing knowledge on epigenetics and BC carcinogenesis to overcome the current challenges. Hence, this review aims to shed light and discuss the current state of epigenetics research in the diagnosis and management of BC.

Other Information

Published in: Seminars in Cancer Biology
License: http://creativecommons.org/licenses/by/4.0/
See article on publisher's website: https://dx.doi.org/10.1016/j.semcancer.2020.08.009

Funding

Open Access funding provided by the Qatar National Library

History

Language

  • English

Publisher

Elsevier BV

Publication Year

  • 2022

License statement

This Item is licensed under the Creative Commons Attribution 4.0 International License

Institution affiliated with

  • Hamad Medical Corporation
  • Hamad General Hospital - HMC
  • Academic Health System - HMC
  • Interim Translational Research Institute - HMC
  • Dermatology Institute - HMC
  • Education and Research - HMC
  • National Center for Cancer Care and Research - HMC
  • Sidra Medicine
  • Qatar University
  • Laboratory Animal Research Center - QU

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