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Effectiveness of influenza vaccination against SARS-CoV-2 infection among healthcare workers in Qatar

journal contribution
submitted on 2023-11-02, 11:02 and posted on 2023-11-02, 11:42 authored by Elias Tayar, Sami Abdeen, Muna Abed Alah, Hiam Chemaitelly, Iheb Bougmiza, Houssein H. Ayoub, Anvar Hassan Kaleeckal, Ali Nizar Latif, Riyazuddin Mohammad Shaik, Hamad Eid Al-Romaihi, Mohamed H. Al-Thani, Roberto Bertollini, Laith J. Abu-Raddad, Abdullatif Al-Khal

Background

Some studies have reported that influenza vaccination is associated with lower risk of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and/or coronavirus disease 2019 (COVID-19) morbidity and mortality. This study aims to estimate effectiveness of influenza vaccination, using Abbott’s quadrivalent Influvac Tetra vaccine, against SARS-CoV-2 infection and against severe COVID-19.

Methods

This matched, test-negative, case-control study was implemented on a population of 30,774 healthcare workers (HCWs) in Qatar during the 2020 annual influenza vaccination campaign, September 17, 2020-December 31, 2020, before introduction of COVID-19 vaccination.

Results

Of 30,774 HCWs, 576 with PCR-positive tests and 10,033 with exclusively PCR-negative tests were eligible for inclusion in the study. Matching by sex, age, nationality, reason for PCR testing, and PCR test date yielded 518 cases matched to 2058 controls. Median duration between influenza vaccination and the PCR test was 43 days (IQR, 29–62). Estimated effectiveness of influenza vaccination against SARS-CoV-2 infection> 14 days after receiving the vaccine was 29.7% (95% CI: 5.5–47.7%). Estimated effectiveness of influenza vaccination against severe, critical, or fatal COVID-19 was 88.9% (95% CI: 4.1–98.7%). Sensitivity analyses confirmed the main analysis results.

Conclusions

Recent influenza vaccination is associated with a significant reduction in the risk of SARS-CoV-2 infection and COVID-19 severity.

Other Information

Published in: Journal of Infection and Public Health
License: http://creativecommons.org/licenses/by/4.0/
See article on publisher's website: https://dx.doi.org/10.1016/j.jiph.2022.12.016

Funding

Open Access funding provided by the Qatar National Library

History

Language

  • English

Publisher

Elsevier

Publication Year

  • 2023

License statement

This Item is licensed under the Creative Commons Attribution 4.0 International License

Institution affiliated with

  • Weill Cornell Medicine - Qatar
  • Hamad Medical Corporation
  • Primary Health Care Corporation
  • Qatar University
  • College of Arts and Sciences - QU
  • Qatar University Health - QU
  • College of Health Sciences - QU HEALTH
  • Ministry of Public Health - State of Qatar

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    Weill Cornell Medicine - Qatar

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