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Obesity Reviews - 2024 - AlMarzooqi - Deciphering the complex interplay of obesity epithelial barrier dysfunction and.pdf (3.27 MB)

Deciphering the complex interplay of obesity, epithelial barrier dysfunction, and tight junction remodeling: Unraveling potential therapeutic avenues

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submitted on 2024-06-05, 06:15 and posted on 2024-06-05, 06:16 authored by Sara K. AlMarzooqi, Fajr Almarzooqi, Hana Q. Sadida, Jayakumar Jerobin, Ikhlak Ahmed, Abdul‐Badi Abou‐Samra, Khalid A. Fakhro, Punita Dhawan, Ajaz A. Bhat, Ammira S. Al‐Shabeeb Akil

Obesity stands as a formidable global health challenge, predisposing individuals to a plethora of chronic illnesses such as cardiovascular disease, diabetes, and cancer. A confluence of genetic polymorphisms, suboptimal dietary choices, and sedentary lifestyles significantly contribute to the elevated incidence of obesity. This multifaceted health issue profoundly disrupts homeostatic equilibrium at both organismal and cellular levels, with marked alterations in gut permeability as a salient consequence. The intricate mechanisms underlying these alterations have yet to be fully elucidated. Still, evidence suggests that heightened inflammatory cytokine levels and the remodeling of tight junction (TJ) proteins, particularly claudins, play a pivotal role in the manifestation of epithelial barrier dysfunction in obesity. Strategic targeting of proteins implicated in these pathways and metabolites such as short‐chain fatty acids presents a promising intervention for restoring barrier functionality among individuals with obesity. Nonetheless, recognizing the heterogeneity among affected individuals is paramount; personalized medical interventions or dietary regimens tailored to specific genetic backgrounds and allergy profiles may prove indispensable. This comprehensive review delves into the nexus of obesity, tight junction remodeling, and barrier dysfunction, offering a critical appraisal of potential therapeutic interventions.

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Published in: Obesity Reviews
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Open Access funding provided by the Qatar National Library.



  • English



Publication Year

  • 2024

License statement

This Item is licensed under the Creative Commons Attribution 4.0 International License.

Institution affiliated with

  • Sidra Medicine
  • Hamad Medical Corporation
  • Qatar Metabolic Institute - HMC
  • Weill Cornell Medicine - Qatar
  • Hamad Bin Khalifa University
  • College of Health and Life Sciences - HBKU

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