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Corneal nerve and endothelial cell damage in patients with transient ischemic attack and minor ischemic stroke

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Version 2 2024-03-12, 08:57
Version 1 2024-03-05, 10:53
journal contribution
revised on 2024-03-12, 08:56 and posted on 2024-03-12, 08:57 authored by Hoda Gad, Adnan Khan, Naveed Akhtar, Saadat Kamran, Ahmed El-Sotouhy, Soha R. Dargham, Ioannis N. Petropoulos, Georgios Ponirakis, Ashfaq Shuaib, Leopold J. Streletz, Rayaz A. Malik

Objective

To determine if corneal confocal microscopy can identify corneal nerve and endothelial cell abnormalities and may be useful in the prognostication of patients with transient ischemic attack [1] or minor ischemic stroke (IS).


Methods

Thirty-six patients admitted with TIA (n = 14) or minor IS (n = 22) underwent transcranial Doppler evaluation and corneal confocal microscopy and were compared with 18 healthy controls.


Results

Corneal nerve fiber density (P = 0.002), branch density (P = 0.004) and fiber length (P = 0.004) were significantly lower in patients with TIA or minor IS compared to controls, with no difference between patients with TIA and minor IS. Endothelial cell density (P = 0.003) was lower and endothelial cell area (P = 0.003) and perimeter (P = 0.006) were significantly higher in patients with TIA or minor IS compared to controls, with no difference between patients with TIA and minor IS. There were no differences in corneal nerve or endothelial cell morphology between patients with and without abnormal cerebrovascular reactivity. HbA1c was independently associated with CNFL, and endothelial cell polymegathism and pleomorphism were associated with both HbA1c and total cholesterol.


Conclusion

Corneal confocal microscopy identifies corneal nerve fiber loss and endothelial cell abnormalities in patients with TIA and minor IS and independent associations with HbA1c and cholesterol.

Other Information

Published in: PLOS ONE
License: http://creativecommons.org/licenses/by/4.0/
See article on publisher's website: https://dx.doi.org/10.1371/journal.pone.0213319

Funding

Open Access funding provided by the Qatar National Library.

History

Language

  • English

Publisher

Public Library of Science (PLoS)

Publication Year

  • 2019

License statement

This Item is licensed under the Creative Commons Attribution 4.0 International License.

Institution affiliated with

  • Weill Cornell Medicine - Qatar
  • Hamad Medical Corporation

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