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10.1016_j.rmcr.2023.101920.pdf (1.96 MB)

Comprehensive genomic profiling of a metastatic small cell lung carcinoma with a complete and long-term response to atezolizumab: A case report

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submitted on 2023-12-19, 05:16 and posted on 2024-01-10, 05:32 authored by Kresimir Tomic, Dragana Karan Krizanac, Faruk Skenderi, Kristina Krpina, Andrea Carapina Bilic, Kristina Galic, Zoran Gatalica, Semir Vranic

Small cell lung cancer (SCLC) is a highly aggressive malignancy with a poor outcome. We present the case of a 57-year-old male patient with extensive-stage (ES-SCLC) treated with chemotherapy and atezolizumab. A complete response was achieved with a long remission of ∼three years. Comprehensive genomic profiling (CGP) of the tumor revealed high tumor mutation burden (13 mutations/Mb) and mutations of TP53, RB1 and ERCC4 genes. This case study confirms that a complete response to chemoimmunotherapy may be achieved in the case of ES-SCLC. It further provides the additional value of CGP and predictive testing in the management of ES-SCLC.

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Published in: Respiratory Medicine Case Reports
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Open Access funding provided by the Qatar National Library.



  • English



Publication Year

  • 2023

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This Item is licensed under the Creative Commons Attribution 4.0 International License.

Institution affiliated with

  • Qatar University
  • Qatar University Health - QU
  • College of Medicine - QU HEALTH