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Journal of Immunology Research - 2017 - Toor - Comparison of Myeloid Cells in Circulation and in the Tumor Microenvironment.pdf (1.47 MB)

Comparison of Myeloid Cells in Circulation and in the Tumor Microenvironment of Patients with Colorectal and Breast Cancers

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submitted on 2024-06-30, 09:16 and posted on 2024-06-30, 09:18 authored by Salman M. Toor, Eyad Elkord

We have previously reported levels of myeloid cells in the periphery and in the tumor microenvironment (TME) of patients with primary breast cancer (PBC) and colorectal cancer (CRC). We found that both PBC and CRC patients have significantly higher levels of granulocytic and immature myeloid cells in the TME. Additionally, we reported an expansion of circulating granulocytic myeloid cells in CRC patients, but not in PBC patients. In this report, we compared levels of myeloid cells between these two common cancers and have added data from more cancer patients. We also investigated associations between clinical stage/histological grade of tumors and levels of myeloid cells in cancer patients. We found that although granulocytic myeloid cells were expanded in the TME of both PBC and CRC patients, the levels of these cells were significantly higher in the TME of CRC patients. Moreover, our results indicate that increased levels of circulating granulocytic myeloid cells are associated with poorly differentiated tumors in CRC patients. Taken together, this work suggests that CRC patients may benefit more from the development of therapeutic agents to promote myeloid cell differentiation or inhibition for the reversal of immune suppression.

Other Information

Published in: Journal of Immunology Research
License: http://creativecommons.org/licenses/by/4.0/
See article on publisher's website: https://dx.doi.org/10.1155/2017/7989020

Funding

Terry Fox Foundation (21M094).

United Arab Emirates Program of Advanced Research (31M190).

History

Language

  • English

Publisher

Hindawi

Publication Year

  • 2017

License statement

This Item is licensed under the Creative Commons Attribution 4.0 International License.

Institution affiliated with

  • Hamad Bin Khalifa University
  • College of Science and Engineering - HBKU
  • Qatar Biomedical Research Institute - HBKU
  • Cancer Research Center - QBRI