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Clinical presentation and outcomes of peripartum cardiomyopathy in the Middle East: a cohort from seven Arab countries

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submitted on 2023-03-15, 08:03 and posted on 2023-03-16, 06:22 authored by Amar M. Salam, Mohamed Badie Ahmed, Kadhim Sulaiman, Rajvir Singh, Mohammed Alhashemi, Alison S. Carr, Alawi A. Alsheikh‐Ali, Khalid F. AlHabib, Ibrahim Al‐Zakwani, Prashanth Panduranga, Nidal Asaad, Abdulla Shehab, Wael AlMahmeed, Jassim Al Suwaidi

Aims

Published data on the clinical presentation of peripartum cardiomyopathy (PPCM) are very limited particularly from the Middle East. The aim of this study was to examine the clinical presentation, management, and outcomes of patients with PPCM using data from a large multicentre heart failure (HF) registry from the Middle East.

Methods and results

From February to November 2012, a total of 5005 consecutive patients with HF were enrolled from 47 hospitals in 7 Middle East countries. From this cohort, patients with PPCM were identified and included in this study. Clinical features, in-hospital, and 12 months outcomes were examined. During the study period, 64 patients with PPCM were enrolled with a mean age of 32.5 ± 5.8 years. Family history was identified in 11 patients (17.2%) and hypertension in 7 patients (10.9%). The predominant presenting symptom was dyspnoea New York Heart Association class IV in 51.6%, class III in 31.3%, and class II in 17.2%. Basal lung crepitations and peripheral oedema were the predominant signs on clinical examination (98.2% and 84.4%, respectively). Most patients received evidence-based HF therapies. Inotropic support and mechanical ventilation were required in 16% and 5% of patients, respectively. There was one in-hospital death (1.6%), and after 1 year of follow-up, nine patients were rehospitalized with HF (15%), and one patient died (1.6%).

Conclusions

A high index of suspicion of PPCM is required to make the diagnosis especially in the presence of family history of HF or cardiomyopathy. Further studies are warranted on the genetic basis of PPCM.

Other Information

Published in: ESC Heart Failure
License: http://creativecommons.org/licenses/by-nc/4.0/
See article on publisher's website: http://dx.doi.org/10.1002/ehf2.13030

History

Language

  • English

Publisher

Wiley

Publication Year

  • 2020

Institution affiliated with

  • Qatar University
  • Hamad Medical Corporation

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