Manara - Qatar Research Repository
000516747.pdf (315.27 kB)

Chronic Myeloid Leukemia in a Patient with Hepatitis B Virus Infection: A Case Report

Download (315.27 kB)
Version 2 2023-11-27, 10:31
Version 1 2023-07-04, 05:01
journal contribution
revised on 2023-11-27, 10:28 and posted on 2023-11-27, 10:31 authored by Yousef Mohammed Ali Hailan, Deena Mudawi, Mohamed A. Yassin

Chronic myeloid leukemia (CML) is a myeloproliferative disorder diagnosed by demonstrating the Philadelphia chromosome (Ph) or the BCR-ABL fusion gene. Tyrosine kinase inhibitors (TKIs) are the standard of therapy. There are increasing reports of hepatitis B virus reactivation (HBVr) in patients on this treatment. We report a case of a 46-year-old male patient diagnosed to have CML in the chronic phase and resolved hepatitis B infection. He was treated with imatinib as upfront therapy for CML and with lamivudine as prophylaxis against HBVr. The patient tolerated both treatments well with no adverse effects. The aim is to address the deficiencies in the literature in regard to managing these patients, prevention, and follow-up. 

Other Information

Published in: Case Reports in Oncology
See article on publisher's website: 


Open Access funding provided by the Qatar National Library.



  • English



Publication Year

  • 2021

License statement

This Item is licensed under the Creative Commons Attribution-NonCommercial 4.0 International License.

Institution affiliated with

  • Hamad Medical Corporation
  • Hamad General Hospital - HMC
  • National Center for Cancer Care and Research - HMC