Ca2+ signaling and lipid transfer ‘pas a deux’ at ER-PM contact sites orchestrate cell migration
journal contribution
submitted on 2023-10-03, 08:42 and posted on 2023-10-03, 08:50 authored by Khaled MachacaContact sites between the endoplasmic reticulum (ER) and plasma membrane (PM) regulate both non-vesicular lipid transfer as well as Ca2+ signaling with multiple interactions between the two pathways. Here I discuss recent findings that offer exciting insights into the role of store-operated Ca2+ entry (SOCE), Oxysterol-binding protein (OSBP)-related proteins ORP3, Arf5 and the Arf GEF IQSec1 in this crosstalk and how they regulate cell migration and focal adhesion disassembly.
Other Information
Published in: Cell Calcium
License: http://creativecommons.org/licenses/by/4.0/
See article on publisher's website: https://dx.doi.org/10.1016/j.ceca.2020.102226
Funding
Open Access funding provided by the Qatar National Library.
Qatar National Research Fund (NPRP12S-0212-190074), Physiological association between diabetes mellitus and cardiac arrhythmia.
History
Language
- English
Publisher
ElsevierPublication Year
- 2020
License statement
This Item is licensed under the Creative Commons Attribution 4.0 International License.Institution affiliated with
- Weill Cornell Medicine - Qatar
