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Association of vitamin D3 and its metabolites in patients with and without type 2 diabetes and their relationship to diabetes complications

journal contribution
submitted on 2024-05-29, 09:56 and posted on 2024-05-29, 10:59 authored by Alexandra E. Butler, Soha R. Dargham, Aishah Latif, Haira R. Mokhtar, Amal Robay, Omar M. Chidiac, Amin Jayyousi, Jassim Al Suwaidi, Ronald G. Crystal, Charbel Abi Khalil, Stephen L. Atkin

Background

Epidemiological studies have suggested that vitamin D deficiency is associated with the development of type 2 diabetes (T2DM) and is related to diabetes complications. This study was undertaken to determine the relationship between diabetes complications and cardiovascular risk factors with vitamin D3 and its metabolites: 1,25-dihydroxyvitamin D3 (1,25(OH)2D3), 25-hydroxyvitamin D3 (25(OH)D3), 24,25-dihydroxyvitamin D3 (24,25(OH)2D3); and 25-hydroxy-3epi-vitamin D3 (3epi25(OH)D3).

Methods

750 Qatari subjects, 460 (61.3%) with and 290 (38.7%) without T2DM, who were not taking vitamin D3 supplements, participated in this cross-sectional, observational study. Plasma concentrations of vitamin D3 and its metabolites were measured by liquid chromatography tandem mass spectrometry analysis.

Results

T2DM subjects had lower concentrations of all vitamin D3 metabolites ( p < 0.001) except 3epi25(OH)D3 ( p < 0.071). Males had higher concentrations of all vitamin D3 metabolites ( p < 0.001). In the T2DM subjects, lower 25(OH)D3 was associated with retinopathy ( p < 0.03) and dyslipidemia ( p < 0.04), but not neuropathy or vascular complications; lower 1,25(OH)2D3 was associated with hypertension ( p < 0.009), dyslipidemia ( p < 0.003) and retinopathy ( p < 0.006), and coronary artery disease ( p < 0.012), but not neuropathy; lower 24,25(OH)2D3 concentrations were associated with dyslipidemia alone ( p < 0.019); 3epi25(OH)D3 associated with diabetic neuropathy alone ( p < 0.029). In nondiabetics, 25(OH)D3, 1,25(OH)2D3 and 24,25(OH)2D3 were associated with dyslipidemia ( p < 0.001, p < 0.001, p < 0.015, respectively) and lower 1,25(OH)2D3 was associated with hypertension ( p < 0.001). Spearman’s correlation showed 1,25(OH)2D3 to be negatively correlated to age and diabetes duration.

Conclusions

Different diabetes complications were associated with differing vitamin D parameters, with diabetic retinopathy related to lower 25(OH)D3 and 1,25(OH)2D3 levels, hypertension significantly associated with lower 1,25(OH)2D3, while dyslipidemia was associated with lower 25(OH)D3, 1,25(OH)2D3 and 24,25(OH)2D3. While 25(OH)D metabolites were lower in females, there was not an exaggeration in complications.

Other Information

Published in: Therapeutic Advances in Chronic Disease
License: https://creativecommons.org/licenses/by-nc/4.0/
See article on publisher's website: https://dx.doi.org/10.1177/2040622320924159

Funding

Qatar National Research Fund (NPRP9-169-3-024), Modeling vascular complications of type 2 diabetes using in vitro derived endothelial-cardiomyocytes.

History

Language

  • English

Publisher

Sage

Publication Year

  • 2020

License statement

This Item is licensed under the Creative Commons Attribution-NonCommercial 4.0 International License.

Institution affiliated with

  • Hamad Bin Khalifa University
  • Qatar Biomedical Research Institute - HBKU
  • Diabetes Research Center - QBRI
  • Weill Cornell Medicine - Qatar
  • Hamad Medical Corporation
  • Heart Hospital - HMC
  • Qatar Anti-Doping Commission
  • Anti-Doping Laboratory Qatar - QA-DC

Methodology

750 Qatari subjects, 460 (61.3%) with and 290 (38.7%) without T2DM, who were not taking vitamin D3 supplements, participated in this cross-sectional, observational study. Plasma concentrations of vitamin D3 and its metabolites were measured by liquid chromatography tandem mass spectrometry analysis.

Geographic coverage

Qatar