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Association of single nucleotide polymorphisms with dyslipidemia and risk of metabolic disorders in the State of Qatar

journal contribution
submitted on 2024-08-26, 05:51 and posted on 2024-08-26, 05:52 authored by Dalal Al‐Sharshani, Dinesh Velayutham, Muthanna Samara, Reham Gazal, Ayman Al Haj Zen, Mohamed A. Ismail, Mahmoud Ahmed, Gheyath Nasrallah, Salma Younes, Nasser Rizk, Sara Hammuda, M. Walid Qoronfleh, Thomas Farrell, Hatem Zayed, Palli Valapila Abdulrouf, Manar AlDweik, John Paul Ben Silang, Alaa Rahhal, Rana Al‐Jurf, Ahmed Mahfouz, Amar Salam, Hilal Al Rifai, Nader I. Al‐Dewik

Background

Dyslipidemia is recognized as one of the risk factors of cardiovascular diseases (CVDs), type 2 diabetes mellitus (T2DM), and non-alcoholic fatty liver disease (NAFLD).

Objective

The study aimed to investigate the association between selected single nucleotide polymorphisms (SNPs) with dyslipidemia and increased susceptibility risks of CVD, NAFLD, and/or T2DM in dyslipidemia patients in comparison with healthy control individuals from the Qatar genome project.

Methods

A community-based cross-sectional study was conducted among 2933 adults (859 dyslipidemia patients and 2074 healthy control individuals) from April to December 2021 to investigate the association between 331 selected SNPs with dyslipidemia and increased susceptibility risks of CVD, NAFLD and/or T2DM, and covariates.

Results

The genotypic frequencies of six SNPs were found to be significantly different in dyslipidemia patients subjects compared to the control group among males and females. In males, three SNPs were found to be significant, the rs11172113 in over-dominant model, the rs646776 in recessive and over-dominant models, and the rs1111875 in dominant model. On the other hand, two SNPs were found to be significant in females, including rs2954029 in recessive model, and rs1801251 in dominant and recessive models. The rs17514846 SNP was found for dominant and over-dominant models among males and only the dominant model for females. We found that the six SNPs linked to gender type had an influence in relation to disease susceptibility. When controlling for the four covariates (gender, obesity, hypertension, and diabetes), the difference between dyslipidemia and the control group remained significant for the six variants. Finally, males were three times more likely to have dyslipidemia in comparison with females, hypertension was two times more likely to be present in the dyslipidemia group, and diabetes was six times more likely to be in the dyslipidemia group.

Conclusion

The current investigation provides evidence of association for a common SNP to coronary heart disease and suggests a sex-dependent effect and encourage potential therapeutic applications.

Other Information

Published in: Molecular Genetics & Genomic Medicine
License: http://creativecommons.org/licenses/by/4.0/
See article on publisher's website: https://dx.doi.org/10.1002/mgg3.2178

Funding

Open Access funding provided by the Qatar National Library.

History

Language

  • English

Publisher

Wiley

Publication Year

  • 2023

License statement

This Item is licensed under the Creative Commons Attribution 4.0 International License.

Institution affiliated with

  • Hamad Bin Khalifa University
  • College of Health and Life Sciences - HBKU
  • College of Humanities and Social Sciences - HBKU
  • Hamad Medical Corporation
  • Hamad General Hospital - HMC
  • Women's Wellness and Research Center - HMC
  • Qatar University
  • College of Arts and Sciences - QU
  • College of Medicine - QU HEALTH
  • College of Health Sciences - QU HEALTH

Geographic coverage

Qatar