Aberrant miRNA expression and protein arginine methyltransferase 5 (PRMT5) in cancer: A review

<p dir="ltr">The search for important factors involved in triggering and promoting cancer cell growth and survival has led to the identification of key players, including transcription factors, chromatin remodelers, epigenetic modifying <u>enzymes</u>, signaling molecules, and <u>miRNAs</u>. However, the interplay and crosstalk between some of these factors and the impact they have on tumorigenesis remains largely unexplored. In this review, we focus on type II <u>protein arginine methyltransferase 5</u> (PRMT5)-mediated epigenetic silencing and its regulatory <u>tumor suppressor miRNAs</u>, as well as the mechanisms by which circular PRMT5 <u>RNA</u> (circ-PRMT5) promotes cancer <u>cell proliferation</u> and survival.</p><h2>Other Information</h2><p dir="ltr">Published in: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.bbamcr.2025.119923" target="_blank">https://dx.doi.org/10.1016/j.bbamcr.2025.119923</a></p>