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A perspective on magnetic core–shell carriers for responsive and targeted drug delivery systems

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journal contribution
submitted on 2024-03-03, 07:51 and posted on 2024-03-03, 07:54 authored by Kholoud Albinali, Moustafa Zagho, Yonghui Deng, Ahmed Elzatahry

Magnetic core–shell nanocarriers have been attracting growing interest owing to their physicochemical and structural properties. The main principles of magnetic nanoparticles (MNPs) are localized treatment and stability under the effect of external magnetic fields. Furthermore, these MNPs can be coated or functionalized to gain a responsive property to a specific trigger, such as pH, heat, or even enzymes. Current investigations have been focused on the employment of this concept in cancer therapies. The evaluation of magnetic core–shell materials includes their magnetization properties, toxicity, and efficacy in drug uptake and release. This review discusses some categories of magnetic core–shell drug carriers based on Fe2O3 and Fe3O4 as the core, and different shells such as poly(lactic-co-glycolic acid), poly(vinylpyrrolidone), chitosan, silica, calcium silicate, metal, and lipids. In addition, the review addresses their recent potential applications for cancer treatment.

Other Information

Published in: International Journal of Nanomedicine
License: https://creativecommons.org/licenses/by/4.0/
See article on publisher's website: https://dx.doi.org/10.2147/ijn.s193981

Funding

Open Access funding provided by the Qatar National Library.

History

Language

  • English

Publisher

Dove Medical Press

Publication Year

  • 2019

License statement

This Item is licensed under the Creative Commons Attribution 4.0 International License

Institution affiliated with

  • Qatar University
  • College of Arts and Sciences - QU