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Macromolecular Symposia - 2023 - Krishnasamy - A Promising Electrochemical Sensor Platform for the Detection of Dopamine.pdf (1.69 MB)

A Promising Electrochemical Sensor Platform for the Detection of Dopamine Using CuO‐NiO/rGO Composite

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submitted on 2024-01-09, 10:48 and posted on 2024-01-14, 11:35 authored by Vinotha Krishnasamy, Gayathri Geetha Nair, Mizaj Shabil Sha, Karthik Kannan, Somaya Al‐maadeed, Asan G.A. Muthalif, Kishor Kumar Sadasivuni

Dopamine plays a significant role in the proper functioning of the central nervous system. Hence, the ability to sense levels of dopamine is pivotal in diagnosis and treatment procedures. For sensing dopamine, a mixed metal oxide nanocomposite (NC) of copper oxide‐nickel oxide/reduced graphene oxide (CuO‐NiO/rGO) is fabricated by the sol–gel method, and it is used to modify the glassy carbon electrode. The structural and morphological characterizations are done by X‐ray diffraction (XRD), Energy dispersive X‐ray (EDAX), Raman, and Scanning electron microscopy (SEM). XRD results exhibit monoclinic CuO, cubic NiO, and hexagonal rGO structures. The Raman studies confirm the D and G bands for rGO. Different electrochemical techniques are used to examine the efficacy of nanocomposite in detecting dopamine. The CuO‐NiO metal oxide NC response compared with the CuO‐NiO/rGO NC shows a better response by rGO containing nanocomposite.

Further, the chronoamperometric method is employed, and the diffusion coefficient is calculated as 1.04 × 10−6 cm2 s−1. The differential pulse voltammetry is carried out to measure the nanocomposite's sensitivity and detection limit (LOD). The catalyst exhibits a sensitivity of 7.2 µA cm−2 mM−1 and a LOD of 0.006 µM. The composite can be used as a flexible skin patch sensor to predict abnormal dopamine levels such as Parkinson's disease.

Other Information

Published in: Macromolecular Symposia
License: http://creativecommons.org/licenses/by/4.0/
See article on publisher's website: https://dx.doi.org/10.1002/masy.202200151

Funding

Open Access funding provided by the Qatar National Library.

History

Language

  • English

Publisher

Wiley

Publication Year

  • 2023

License statement

This Item is licensed under the Creative Commons Attribution 4.0 International License.

Institution affiliated with

  • Qatar University
  • Center for Advanced Materials - QU
  • College of Engineering - QU