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A Novel Green Synthesis of Thalidomide and Analogs

journal contribution
submitted on 2024-06-27, 10:07 and posted on 2024-06-27, 10:08 authored by Ellis Benjamin, Yousef M. Hijji

Thalidomide and its derivatives are currently under investigation for their antiangiogenic, immunomodulative, and anticancer properties. Current methods used to synthesize these compounds involve multiple steps and extensive workup procedures. Described herein is an efficient microwave irradiation green synthesis method that allows preparation of thalidomide and its analogs in a one-pot multicomponent synthesis system. The multicomponent synthesis system developed involves an array of cyclic anhydrides, glutamic acid, and ammonium chloride in the presence of catalytic amounts of 4-N,N-dimethylaminopyridine (DMAP) to produce thalidomide and structurally related compounds within minutes in good isolated yields.

Other Information

Published in: Journal of Chemistry
See article on publisher's website:


Qatar National Research Fund (NPRP-.7-495-1-094), Development and characterization of colorimetric anion and cation sensors for application in water monitoring and purification.



  • English



Publication Year

  • 2017

License statement

This Item is licensed under the Creative Commons Attribution 4.0 International License.

Institution affiliated with

  • Qatar University
  • College of Arts and Sciences - QU