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A Comparative Study of High-intensity Rosuvastatin Versus Atorvastatin Therapy Post-acute Coronary Syndrome Using Real-world Data

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submitted on 2023-10-25, 06:02 and posted on 2023-10-25, 06:40 authored by Alaa Rahhal, Fadi Khir, Bassant Orabi, Salma Chbib, Osama Al-Khalaila, Mohamed Salah Abdelghani, Omnia Osman, Amr Azzam Ashour, Mohammad Al-Awad, Ahmed Mahfouz, Ahmed Awaisu, Amer Hussien Aljundi, Yaser Alahmad, Sumaya Alyafei, Abdul Rahman Arabi

A high-intensity statin is recommended for the secondary prevention of cardiovascular diseases (CVD). However, real-world evidence of the effectiveness of rosuvastatin following acute coronary syndrome (ACS) is scarce. This retrospective cohort study included patients diagnosed with ACS to compare between the 2 high-intensity statin therapies (rosuvastatin vs atorvastatin) in terms of a primary composite outcome of CVD-associated death, non-fatal ACS, and non-fatal stroke at 1 month and 12 months post discharge. The primary effectiveness outcome did not differ between the 2 groups at 1 month (1.3% vs 1%; aHR = 1.64, 95% CI 0.55-4.94, P= 0.379) and at 12 months (4.8% vs 3.5%; aHR = 1.48, 95% CI 0.82-2.67, P= 0.199). Similarly, the 2 groups had comparable safety outcomes. In conclusion, the use of high-intensity rosuvastatin compared to high-intensity atorvastatin therapy in patients with ACS had resulted in comparable cardiovascular effectiveness and safety outcomes.

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Published in: Current Problems in Cardiology
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Open Access funding provided by the Qatar National Library



  • English



Publication Year

  • 2022

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This Item is licensed under the Creative Commons Attribution 4.0 International License

Institution affiliated with

  • Hamad Medical Corporation
  • Heart Hospital - HMC
  • Hamad General Hospital - HMC
  • Qatar University
  • Qatar University Health - QU
  • College of Pharmacy - QU HEALTH